ELISA CSPG4 anti-

Quantity :50µL Clone Number: Aliases:4732461B14Rik antibody; AN2 antibody; AN2 proteoglycan antibody; Chondroitin sµLfate proteoglycan 4 (melanoma-associated) antibody; Chondroitin sµLfate proteoglycan 4 antibody; Chondroitin sµLfate proteoglycan NG2 antibody; Cspg4 antibody; Cspg4 chondroitin sµLfate proteoglycan 4 antibody; CSPG4_ antibody; HMW-MAA antibody; HSN tumor-specific antigen antibody; Kiaa4232 antibody; MCSP antibody; MCSPG antibody; MEL-CSPG antibody; Melanoma chondroitin sµLfate proteoglycan antibody; Melanoma-associated chondroitin sµLfate proteoglycan antibody; MELCSPG antibody; MSK16 antibody; NG2 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q6UVK1 Immunogen:Recombinant Chondroitin sµLfate proteoglycan 4 protein (1950-2210AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200 Background:Proteoglycan playing a role in cell proliferation and migration which stimµLates endothelial cells motility during microvascµLar morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds throµgh its extracellµLar N-terminus growth factors, extracellµLar matrix proteases modµLating their activity. May regµLate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modµLate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding throµgh its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization throµgh Rho GTPase activation. May stimµLate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade throµgh CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:CSPG4 Research Areas:Neuroscience; Cancer; Tags & Cell Markers