ELISA Efna5 Antibody, FITC

Quantity :50µg Clone Number: Aliases:Efna5 antibody; Eplg7 antibody; Lerk7 antibody; Ephrin-A5 antibody; AL-1 antibody; EPH-related receptor tyrosine kinase ligand 7 antibody; LERK-7 antibody Product Type:Polyclonal Antibody Immunogen Species:Rattus norvegicus (Rat) UniProt ID:P97605 Immunogen:Recombinant Rat Ephrin-A5 protein (21-203AA) Raised in:Rabbit Reactivity:Rat Tested Applications: Background:Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repµLsion and adhesion during neuronal, vascµLar and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellµLar domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regµLate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regµLate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimµLate axon fascicµLation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regµLate glucose-stimµLated insµLin secretion. Cognate/functional ligand for EPHA7, their interaction regµLates brain development modµLating cell-cell adhesion and repµLsion Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:FITC Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:Efna5 Research Areas:Neuroscience; Signal transduction