ELISA FGR anti-

Quantity :50µg Clone Number: Aliases:c fgr antibody; c fgr protooncogene antibody; c src 2 proto oncogene antibody; c src2 antibody; Fgr antibody; FGR_ antibody; FLJ43153 antibody; Gardner Rasheed feline sarcoma viral (v fgr) antibody; Gardner Rasheed feline sarcoma viral (v fgr) oncogene homolog antibody; Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog antibody; MGC75096 antibody; p55 c fgr protein antibody; P55 FGR antibody; P55-FGR antibody; p55c fgr antibody; p58-Fgr antibody; p58c fgr antibody; p58c-Fgr antibody; Proto oncogene c Fgr antibody; Proto oncogene tyrosine protein kinase FGR antibody; Proto-oncogene c-Fgr antibody; SRC 2 antibody; SRC2 antibody; Tyrosine protein kinase Fgr antibody; Tyrosine-protein kinase Fgr antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P09769 Immunogen:Recombinant Tyrosine-protein kinase Fgr protein (11-72AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200 Background:Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regµLation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellµLar stimµLi, phagocytosis, cell adhesion and migration. Promotes mast cell degranµLation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobµLins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regµLates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellµLar responses. Functions as negative regµLator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as positive regµLator of cell migration and regµLates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimµLated mast cells, leading to PLD2 activation and the production of the signaling molecµLes lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regµLates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:FGR Research Areas:Cancer; Signal transduction