ELISA DTX1 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:Deltex 1; E3 ubiquitin ligase antibody; Deltex antibody; Deltex homolog 1 (Drosophila) antibody; Deltex homolog 1 antibody; Deltex protein 1 antibody; Deltex-1 antibody; Deltex1 antibody; dtx1 antibody; DTX1_ antibody; E3 ubiquitin protein ligase DTX1 antibody; E3 ubiquitin-protein ligase DTX1 antibody; FXI-T1 antibody; Fxit 1 antibody; Fxit1 antibody; hDTX1 antibody; hDx 1 antibody; mDTX1 antibody; Protein deltex 1 antibody; Protein deltex-1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q86Y01 Immunogen:Recombinant E3 ubiquitin-protein ligase DTX1 protein (261-410AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, sµggesting that it may regµLate the Notch pathway via some ubiquitin ligase activity (By similarity). RegµLator of Notch signaling, a signaling pathway involved in cell-cell communications that regµLates a broad spectrum of cell-fate determinations. Mainly acts as a positive regµLator of Notch, but it also acts as a negative regµLator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, sµggesting that it can antagonize NOTCH1. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:DTX1 Research Areas:Epigenetics and Nuclear Signaling; Neuroscience; Cell biology