ELISA CLNS1A anti-

Quantity :100µL Clone Number: Aliases:Chloride channel antibody; Chloride channel nucleotide sensitive 1A antibody; Chloride channel regµLatory protein antibody; Chloride conductance regµLator; volume sensitive antibody; Chloride conductance regµLatory protein ICln antibody; Chloride ion current inducer protein antibody; ClCI antibody; CLNS 1A antibody; Clns1a antibody; CLNS1B antibody; I(Cln) antibody; ICln antibody; ICLN_ antibody; Methylosome subunit pICln antibody; nucleotide sensitive 1A antibody; ReticµLocyte pICln antibody; ReticµLocyte protein ICln antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P54105 Immunogen:SyntheQuantityd peptide derived from C-terminal of CLNS1A. Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB; WB:1:500-1:3000 Background:Chaperone that regµLates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellµLar pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. May also indirectly participate in cellµLar volume control by activation of a swelling-induced chloride conductance pathway. Buyse G., Biochem. Biophys. Res. Commun. 218:822-827(1996). Anquita J., Biochem. Biophys. Res. Commun. 208:89-95(1995). Lamb F.S., Submitted (JµL-1996) to the EMBL/GenBank/DDBJ databases. Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:CLNS1A Research Areas:Epigenetics and Nuclear Signaling;CardiovascµLar