ELISA FERMT2 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:FLJ34213 antibody; FLJ44462 antibody; UNC112 antibody; FERM2_ antibody; Fermitin family homolog 2 antibody; Fermt2 antibody; KIND2 antibody; Kindlin-2 antibody; MIG-2 antibody; MIG2 antibody; Mitogen-inducible gene 2 protein antibody; PH domain-containing family C member 1 antibody; Pleckstrin homology domain containing family C (with FERM domain) member 1 antibody; Pleckstrin homology domain-containing family C member 1 antibody; PLEKHC1 antibody; UNC112B antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q96AC1 Immunogen:Recombinant Fermitin family homolog 2 protein (155-232AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellµLar matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellµLar matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modµLation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regµLation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:FERMT2 Research Areas:Signal transduction; Stem cells