ELISA DSP anti-

Quantity :50µL Clone Number: Aliases:250/210 kDa paraneoplastic pemphigus antigen antibody; DCWHKTA antibody; Desmoplakin (DPI DPII) antibody; Desmoplakin antibody; Desmoplakin I antibody; Desmoplakin II antibody; DESP_ antibody; DP antibody; DP I antibody; DP II antibody; DPI antibody; DPII antibody; DSP antibody; KPPS2 antibody; PPKS 2 antibody; PPKS2 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P15924 Immunogen:Synthetic peptide of DSP Raised in:Rabbit Reactivity:, Mouse Tested Applications:ELISA, IHC; ELISA:1:2000-1:5000, IHC:1:50-1:200 Background:Desmosomes are intercellµLar junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen affinity purification Conjµgate:Non-conjµgated Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:DSP Research Areas:Signal transduction